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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ANGPT2
All Species:
30.61
Human Site:
Y459
Identified Species:
74.81
UniProt:
O15123
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15123
NP_001112359.1
496
56919
Y459
P
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
Chimpanzee
Pan troglodytes
XP_001145488
495
56844
Y458
P
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
Rhesus Macaque
Macaca mulatta
XP_001097949
495
56768
Y458
P
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
Dog
Lupus familis
XP_852012
498
55980
Y461
L
S
N
L
N
G
I
Y
Y
P
A
R
H
H
V
Cat
Felis silvestris
Mouse
Mus musculus
O35608
496
56557
Y459
P
S
N
L
N
G
Q
Y
Y
P
Q
K
Q
N
T
Rat
Rattus norvegicus
O35462
496
56499
Y459
P
S
N
L
N
G
Q
Y
Y
P
Q
K
Q
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505935
496
56838
Y459
P
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
Chicken
Gallus gallus
NP_990148
407
46628
Y371
S
N
L
N
G
M
Y
Y
P
L
R
Q
N
N
N
Frog
Xenopus laevis
Q5XK91
457
51018
R421
N
L
N
G
Q
Y
L
R
G
H
H
A
S
Y
A
Zebra Danio
Brachydanio rerio
NP_571888
513
58342
Y475
P
S
N
L
N
G
V
Y
Y
R
Q
G
Q
H
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
52.6
N.A.
85.2
86.4
N.A.
90.5
71.1
28.8
55.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
99.1
72.4
N.A.
93.1
93.5
N.A.
95.1
77
47.5
75.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
60
N.A.
86.6
86.6
N.A.
100
13.3
6.6
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
93.3
93.3
N.A.
100
33.3
13.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
10
80
0
0
10
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
10
0
10
20
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
% K
% Leu:
10
10
10
80
0
0
10
0
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
40
0
0
0
0
0
0
0
0
% M
% Asn:
10
10
90
10
80
0
0
0
0
0
0
0
10
70
10
% N
% Pro:
70
0
0
0
0
0
0
0
10
70
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
20
0
0
0
70
10
70
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
10
10
50
0
0
0
% R
% Ser:
10
80
0
0
0
0
0
0
0
0
0
0
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
60
% T
% Val:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
10
90
80
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _